胃蛋白酶抑制剂, 来源：微生物, ≥75% (HPLC)
| 【编号】：113168 【产品名称】：胃蛋白酶抑制剂, 来源：微生物, ≥75% (HPLC) 【规格】：5mg 【用途】：   胃蛋白酶抑制剂, 来源：微生物, ≥75% (HPLC)
Product Name： Pepstatin
别名：抑肽素
CAS号：26305-03-3
分子式：C34H63N5O9
分子量：685.89
用途： Can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes. For this application, the working concentration is typically between 1-10 μM.www.atcc360.com
特定比重： 1.117
贮存： 2-8℃保存。
生化和生理学机理： Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1：1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases, or serine proteases. Solubilized γ-secretase and retroviral protease are also inhibited by Pepstatin A. It has been used to characterize proteases from several sources.
备注： Pepstatin can be dissolved at 1 mg/ml in 10% (v/v) acetic acid in methanol (9：1 methanol：acetic acid). The inclusion of acetic acid may be necessary to dissolve this peptide in methanol or DMSO. It has been dissolved at 1 to 2 mg/ml in ethanol, but heat may be required for complete dissolution. Solutions of Pepstatin A can be heated as high as 60 °C without any decomposition of the peptide. Stock solutions at 1 mg/ml are stable at least a week at 4 °C. A 1 mM solution in methanol or DMSO is stable for months at -20 °C. If solutions become darker yellow, the reagent is hydrolyzing. A working concentration of 1 μM is stable for at least one day at room temperature.
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