5-氮杂-2'-脱氧胞苷, 98 %
| 【编号】：119533 【产品名称】：5-氮杂-2'-脱氧胞苷, 98 % 【规格】：5mg 【用途】：   5-氮杂-2'-脱氧胞苷, 98 %
Product Name： 5-Aza-2′-deoxycytidine
CAS号：2353-33-5
分子式：C8H12N4O4
分子量：228.21
介绍： Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.www.atcc360.com
生化和生理学机理： 5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.
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| 上一篇：2,2'-脱水-5-甲基尿苷, 98.0% | 下一篇：N4-苯甲酰胞苷, 98% |
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