当前位置:对照品 > 实验试剂 > 生化试剂 >
EBE-A22
  【编号】:126691

  【产品名称】:EBE-A22

  【规格】:5MG

  【用途】:

  EBE-A22

  Product Name: EBE-A22
  CAS号:229476-53-3
  分子式:C17H16BrN3O2
  分子量:374.23
  贮存: 储存温度-20°C
  可溶性: 25°C: DMSO
  生化和生理学机理:
  Description:
  EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive. The brominated anilinoquinazoline derivative PD153035 exhibits a very high affinity and selectivity for the epidermal growth factor receptor tyrosine kinase (EGF-R TK) and shows a remarkable cytotoxicity against several types of tumor cell lines. In contrast, its N-methyl derivative, designated EBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic profile. The present study was performed to explore the possibility that PD153035 and its N-methyl analogue might interact with double-stranded DNA, which is a primary target for many conventional antitumor agents. We studied the strength and mode of binding to DNA of PD153035 and EBE-A22 by means of absorption, fluorescence, and circular and linear dichroism as well as by a relaxation assay using human DNA topoisomerases. The results of various optical and gel electrophoresis techniques co
上一篇:Emricasan, ≥98% 下一篇:JANEX-1



    
    首 页 | 对照品| 标准品| 标准物质| 实验试剂| 培养基| 菌种购买| 新闻中心| 联系我们| 网站地图

    2011-2018 北京莱耀生物版权所有豫ICP备17046142号