ZM323881
【编号】:125400 【产品名称】:ZM323881 【规格】:10MG 【用途】: ZM323881
Product Name: ZM323881
CAS号:193001-14-8
分子式:C22H18FN3O2
分子量:375.4
贮存: 储存温度-20°C
可溶性: DMSO
生化和生理学机理:
ZM323881 is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. ZM323881 selectively inhibits VEGFR-2 (IC50 = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFRβ, FGFR1, EGFR and erbB2 (IC50 > 50 μM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC50 = 8 nM).
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