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QL-IX-55
  【编号】:128082

  【产品名称】:QL-IX-55

  【规格】:5MG

  【用途】:

  QL-IX-55

  Product Name: QL-IX-55
  CAS号:1223002-54-7
  分子式:C24H14F4N4O
  分子量:450.39贮存: 储存温度-20°C
  可溶性: DMSO
  生化和生理学机理:
  The functional target of QL-IX-55 is the ATP-binding site of TOR2 as evidenced by the discovery of resistant alleles of TOR2 through rational design and unbiased selection strategies. QL-IX-55 is capable of potently inhibiting both TOR complex 1 and 2 (TORC1 and TORC2) as demonstrated by biochem. IP kinase assays (IC50 <50 nM) and cellular assays for inhibition of substrate YPK1 phosphorylation. In contrast to rapamycin, QL-IX-55 is capable of inhibiting TORC2-dependent transcription, which suggests that this compd. will be a powerful probe to dissect the Tor2/TORC2-related signaling pathway in yeast.
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