RG2833, ≥98%
【编号】:127721 【产品名称】:RG2833, ≥98% 【规格】:5MG 【用途】: RG2833, ≥98%
Product Name: RG2833
CAS号:1215493-56-3
分子式:C20H25N3O2
分子量:339.43
贮存: 储存温度-20°C
可溶性: 25°C: DMSO
生化和生理学机理:
Description:
IC50 Value: N/A
RGFP 109 is a histone deacetylase inhibitor which can attenuate L-DOPA-induced dyskinesia in the MPTP-lesioned marmoset.
in vitro: N/A
in vivo: RGFP109 had no acute effects on dyskinesia after single or 6 days once-daily treatment (both P > 0.05). However, one week following cessation of RGFP109, dyskinesia and duration of ON-time with disabling dyskinesia were reduced by 37% and 50%, respectively (both P < 0.05), compared to that seen previously with L-DOPA alone. There was no change in anti-parkinsonian actions of, or ON-time duration afforded by, L-DOPA (P > 0.05) [1].
Clinical trial: Phase 1
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