VcMMAE, ≥99%
| 【编号】：125591 【产品名称】：VcMMAE, ≥99% 【规格】：1MG 【用途】：   VcMMAE, ≥99%
Product Name： VcMMAE
CAS号：646502-53-6
分子式：C68H105N11O15
分子量：1316.63
贮存： 储存温度-20°C
可溶性： DMSO
生化和生理学机理：
VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Antibody-drug conjugates (ADCs) are designed to combine the exquisite specificity of antibodies to target tumor antigens with the cytotoxic potency of chemotherapeutic drugs. In vivo studies demonstrated that the peptide-linked conjugates induced regressions and cures of established tumor xenografts with therapeutic indices as high as 60-fold. These conjugates illustrate the importance of linker technology, drug potency and conjugation methodology in developing safe and efficacious mAb-drug conjugates for cancer therapy.
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