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PF-04447943
  【编号】:127232

  【产品名称】:PF-04447943

  【规格】:5MG

  【用途】:

  PF-04447943

  Product Name: PF-04447943
  CAS号:1082744-20-4
  分子式:C20H25N7O2
  分子量:395.46
  贮存: 储存温度-20°C
  可溶性: DMSO
  生化和生理学机理:
  PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor that increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice. PF-04447943 was found to have high affinity (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1-8 and 10-11. Inhibition of phosphodiesterase 9 (PDE9) has been reported to enhance rodent cognitive function and may represent a potential novel approach to improving cognitive dysfunction in Alzheimer's disease.
上一篇:普拉西坦,≥99% 下一篇:PSI-6206, ≥98%



    
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